Journavx is a newly found non-opioid analgesic approved by the FDA in 2025 for the treatment of moderate to severe acute pain in adults. It is a first-in-class, NaV1.8-selective sodium-channel blocker that acts upon peripheral pain signaling, with no effect on opioid receptors. Thus, it is capable of providing adequate pain relief as compared to opioids without causing any addiction, respiratory depression, or constipation-like side effects.

Qulipta (atogepant), is a prescription drug used for the preventive treatment of episodic migraine in adults. This group of medications is called calcitonin gene-related peptide (CGRP) receptor antagonists. Acting mainly on the CGRP receptor, Qulipta prevents migraine attacks from happening in the first place, offering a daily oral medication for those patients who repeatedly undergo such bouts of migraines.

Methocarbamol is a muscle relaxant at the prescription level for immediate relief from acute muscle pain and discomfort due to strain, sprain, or other musculoskeletal disorders. It has a retarding effect on the central nervous system, reducing the severity and frequency of muscle spasms. Often considered together with exercise and rehabilitative treatment in addition to other treatments, Methocarbamol is claimed to exert its sedative and muscle-relaxing effects without directly affecting the muscle.

Naproxen is a general non-steroidal anti-inflammatory drug (NSAID) to relieve various painful conditions. It works by reducing hormones that cause inflammation and pain in the body. It treats arthritis, muscle aches, frequent cramps, tendonitis, or other inflammatory conditions. It is available over-the-counter and by prescription, which means it can be effectively used to treat both acute and chronic pain.

The lidocaine patch is a topical anesthetic product in the form of patches, acting to alleviate localized nerve/muscle pain. These medicated patches contain lidocaine, an analgesic agent that temporarily obstructs the specific nerves from impulses in the area where applied. They are often used against postherpetic neuralgia following shingles, muscle pain, back pain, or even minor injuries. Unlike oral drugs, lidocaine patches deliver pain relief directly over the area without involving the entire body.